Have you seen this page: http://www.clip-shar...duct/templates/
I've worked on specific custom page mods:
Custom Group page: http://www.popmodal....usicvideos/ip#m
Custom Player page: http://www.popmodal....ohen--Nevermind
Customizing a single page is quirky and problematic. Better to have an overall packaged template.
Tweaking templates for every page is a combination of UI design and css, smarty templates work. You also need to QA cross browser and test for unusual conditions like long names, language changes, responsive design. It's an art. I would suggest you go with already made packages. If you want something particular, be prepared to pay for the process.
Hope that helps.